Last updated on 2025-12-20 05:49:58 CET.
| Flavor | Version | Tinstall | Tcheck | Ttotal | Status | Flags |
|---|---|---|---|---|---|---|
| r-devel-linux-x86_64-debian-clang | 2.7.3 | 42.30 | 725.61 | 767.91 | NOTE | |
| r-devel-linux-x86_64-debian-gcc | 2.7.4 | 27.29 | 316.57 | 343.86 | ERROR | |
| r-devel-linux-x86_64-fedora-clang | 2.7.4 | 74.00 | 746.17 | 820.17 | ERROR | |
| r-devel-linux-x86_64-fedora-gcc | 2.7.4 | 71.00 | 721.17 | 792.17 | ERROR | |
| r-devel-windows-x86_64 | 2.7.4 | 55.00 | 620.00 | 675.00 | OK | |
| r-patched-linux-x86_64 | 2.7.4 | 48.41 | 532.53 | 580.94 | OK | |
| r-release-linux-x86_64 | 2.7.4 | 38.49 | 538.35 | 576.84 | OK | |
| r-release-macos-arm64 | 2.7.4 | 12.00 | 125.00 | 137.00 | OK | |
| r-release-macos-x86_64 | 2.7.4 | 32.00 | 608.00 | 640.00 | OK | |
| r-release-windows-x86_64 | 2.7.4 | 51.00 | 592.00 | 643.00 | OK | |
| r-oldrel-macos-arm64 | 2.7.4 | 11.00 | 130.00 | 141.00 | NOTE | |
| r-oldrel-macos-x86_64 | 2.7.4 | 33.00 | 643.00 | 676.00 | NOTE | |
| r-oldrel-windows-x86_64 | 2.7.4 | 73.00 | 760.00 | 833.00 | OK |
Version: 2.7.3
Check: Rd files
Result: NOTE
checkRd: (-1) calc_mc_css.Rd:181: height/width attributes should be in pixels
checkRd: (-1) calc_mc_oral_equiv.Rd:153: height/width attributes should be in pixels
checkRd: (-1) solve_1comp.Rd:155-156: height/width attributes should be in pixels
checkRd: (-1) solve_1comp_lifestage.Rd:164-165: height/width attributes should be in pixels
checkRd: (-1) solve_3comp.Rd:184-185: height/width attributes should be in pixels
checkRd: (-1) solve_3comp2.Rd:188-189: height/width attributes should be in pixels
checkRd: (-1) solve_3comp_lifestage.Rd:195-196: height/width attributes should be in pixels
checkRd: (-1) solve_gas_pbtk.Rd:250-251: height/width attributes should be in pixels
checkRd: (-1) solve_pbtk.Rd:180-181: height/width attributes should be in pixels
checkRd: (-1) solve_pbtk_lifestage.Rd:195-196: height/width attributes should be in pixels
Flavor: r-devel-linux-x86_64-debian-clang
Version: 2.7.4
Check: examples
Result: ERROR
Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: armitage_eval
> ### Title: Armitage In Vitro Distribution Model
> ### Aliases: armitage_eval
>
> ### ** Examples
>
>
> library(httk)
>
> # Check to see if we have info on the chemical:
> "80-05-7" %in% get_cheminfo()
Warning in get_cheminfo() :
Excluding compounds that have one or more needed parameters missing in chem.physical_and_invitro.table.
For model 3compartmentss each chemical must have non-NA values for:Human.Clint, Human.Funbound.plasma, logP, MW
Warning in get_cheminfo() :
Excluding compounds without a 'fup' value (i.e. fup value = NA).
Warning in get_cheminfo() :
Excluding compounds with uncertain 'fup' confidence/credible intervals.
Warning in get_cheminfo() :
Excluding compounds that do not have a clint value or distribution of clint values.
Warning in get_cheminfo() :
Excluding volatile compounds defined as log.Henry >= -4.5.
Warning in get_cheminfo() :
Excluding compounds that are categorized in one or more of the following chemical classes: PFAS.
[1] TRUE
>
> #We do:
> temp <- armitage_eval(casrn.vector = c("80-05-7", "81-81-2"), this.FBSf = 0.1,
+ this.well_number = 384, nomconc = 10)
Error in `[.data.table`(tcdata, IOC_Type_cell == "Base" & is.character(pKa_Accept) & :
attempt access index 92/92 in VECTOR_ELT
Calls: armitage_eval -> %>% -> [ -> [.data.table
Execution halted
Flavor: r-devel-linux-x86_64-debian-gcc
Version: 2.7.4
Check: tests
Result: ERROR
Running ‘3comp_test.R’ [11s/14s]
Comparing ‘3comp_test.Rout’ to ‘3comp_test.Rout.save’ ... OK
Running ‘3compss_test.R’ [11s/13s]
Comparing ‘3compss_test.Rout’ to ‘3compss_test.Rout.save’ ... OK
Running ‘caco2_test.R’ [15s/17s]
Comparing ‘caco2_test.Rout’ to ‘caco2_test.Rout.save’ ... OK
Running ‘cheminfo_test.R’ [6s/9s]
Comparing ‘cheminfo_test.Rout’ to ‘cheminfo_test.Rout.save’ ... OK
Running ‘fetal_pbtk_testing.R’ [7s/9s]
Comparing ‘fetal_pbtk_testing.Rout’ to ‘fetal_pbtk_testing.Rout.save’ ... OK
Running ‘ionization_tests.R’ [3s/4s]
Comparing ‘ionization_tests.Rout’ to ‘ionization_tests.Rout.save’ ... OK
Running ‘ivive_test.R’ [11s/12s]
Running ‘montecarlo_tests.R’ [20s/24s]
Comparing ‘montecarlo_tests.Rout’ to ‘montecarlo_tests.Rout.save’ ... OK
Running ‘other_tests.R’ [9s/11s]
Comparing ‘other_tests.Rout’ to ‘other_tests.Rout.save’ ... OK
Running ‘pbtk_test.R’ [9s/11s]
Comparing ‘pbtk_test.Rout’ to ‘pbtk_test.Rout.save’ ... OK
Running ‘solve_dermal_test.R’ [6s/7s]
Comparing ‘solve_dermal_test.Rout’ to ‘solve_dermal_test.Rout.save’ ... OK
Running ‘solve_gas_test.R’ [7s/8s]
Comparing ‘solve_gas_test.Rout’ to ‘solve_gas_test.Rout.save’ ... OK
Running ‘testthat.R’ [18s/21s]
Running ‘unit_test.R’ [5s/6s]
Comparing ‘unit_test.Rout’ to ‘unit_test.Rout.save’ ... OK
Running the tests in ‘tests/ivive_test.R’ failed.
Complete output:
> # R CMD BATCH --no-timing --no-restore --no-save ivive_test.R ivive_test.Rout
>
> # Get rid of anything in the workspace:
> rm(list=ls())
>
> library(httk)
>
> # Reduce the number of samples used by Monte Carlo to decrease runtime for
> # CRAN checks (never use predictions with only ten draws):
> NSAMP <- 5
>
> # From Honda et al. (2019) (currently only use mean conc's because steady-state
> # calculation does not give max):
> #
> # Default HTTK function arguments correspond to "Honda3"
> #
> # in vivo Conc. Metabolic Clearance In Vivo Conc. In Vitro Conc.
> #Honda1 Veinous (Plasma) Restrictive Free Free
> #Honda2 Veinous Restrictive Free Nominal
> #Honda3 Veinous Restrictive Total Nominal
> #Honda4 Target Tissue Non-restrictive Total Nominal
> #
> # "Honda1" uses plasma concentration, restrictive clearance, and treats the
> # unbound invivo concentration as bioactive. For IVIVE, any input nominal
> # concentration in vitro should be converted to cfree.invitro using
> # \code{\link{armitage_eval}}, otherwise performance will be the same as
> # "Honda2".
> #
> # Use \code{\link{show_honda.ivive()}} to print summary of Honda et al. (2019)
> # results.
>
> # Default HTTK:
> set.seed(12345)
> Css0 <- calc_mc_css(chem.name="bisphenol a",
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> set.seed(12345)
> # This should be the same as calc_mc_oral_equiv:
> signif(3/Css0,4) ==
+ calc_mc_oral_equiv(3.0,chem.name="bisphenol a",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
uM concentration converted to mgpkgpday dose for 0.95 quantile.
95%
TRUE
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
>
> # Honda1:
> set.seed(12345)
> Css1 <- calc_mc_css(chem.name="bisphenol a",
+ calc.analytic.css.arg.list=list(
+ restrictive.clearance = TRUE,
+ bioactive.free.invivo = TRUE),
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> temp <- armitage_eval(
+ casrn.vector = c("80-05-7"),
+ this.FBSf = 0.1,
+ this.well_number = 384,
+ nomconc = 3)
Error in `[.data.table`(tcdata, IOC_Type_cell == "Base" & is.character(pKa_Accept) & :
attempt access index 92/92 in VECTOR_ELT
Calls: armitage_eval -> %>% -> [ -> [.data.table
Execution halted
Flavor: r-devel-linux-x86_64-debian-gcc
Version: 2.7.4
Check: examples
Result: ERROR
Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:
> ### Name: armitage_eval
> ### Title: Armitage In Vitro Distribution Model
> ### Aliases: armitage_eval
>
> ### ** Examples
>
>
> library(httk)
>
> # Check to see if we have info on the chemical:
> "80-05-7" %in% get_cheminfo()
Warning in get_cheminfo() :
Excluding compounds that have one or more needed parameters missing in chem.physical_and_invitro.table.
For model 3compartmentss each chemical must have non-NA values for:Human.Clint, Human.Funbound.plasma, logP, MW
Warning in get_cheminfo() :
Excluding compounds without a 'fup' value (i.e. fup value = NA).
Warning in get_cheminfo() :
Excluding compounds with uncertain 'fup' confidence/credible intervals.
Warning in get_cheminfo() :
Excluding compounds that do not have a clint value or distribution of clint values.
Warning in get_cheminfo() :
Excluding volatile compounds defined as log.Henry >= -4.5.
Warning in get_cheminfo() :
Excluding compounds that are categorized in one or more of the following chemical classes: PFAS.
[1] TRUE
>
> #We do:
> temp <- armitage_eval(casrn.vector = c("80-05-7", "81-81-2"), this.FBSf = 0.1,
+ this.well_number = 384, nomconc = 10)
Error in `[.data.table`(tcdata, IOC_Type_cell == "Base" & is.character(pKa_Accept) & :
attempt access index 92/92 in VECTOR_ELT
Calls: armitage_eval -> %>% -> [ -> [.data.table
Execution halted
Flavors: r-devel-linux-x86_64-fedora-clang, r-devel-linux-x86_64-fedora-gcc
Version: 2.7.4
Check: tests
Result: ERROR
Running ‘3comp_test.R’ [27s/55s]
Comparing ‘3comp_test.Rout’ to ‘3comp_test.Rout.save’ ... OK
Running ‘3compss_test.R’ [25s/41s]
Comparing ‘3compss_test.Rout’ to ‘3compss_test.Rout.save’ ... OK
Running ‘caco2_test.R’ [36s/78s]
Comparing ‘caco2_test.Rout’ to ‘caco2_test.Rout.save’ ... OK
Running ‘cheminfo_test.R’ [15s/29s]
Comparing ‘cheminfo_test.Rout’ to ‘cheminfo_test.Rout.save’ ... OK
Running ‘fetal_pbtk_testing.R’ [19s/30s]
Comparing ‘fetal_pbtk_testing.Rout’ to ‘fetal_pbtk_testing.Rout.save’ ... OK
Running ‘ionization_tests.R’ [6s/16s]
Comparing ‘ionization_tests.Rout’ to ‘ionization_tests.Rout.save’ ... OK
Running ‘ivive_test.R’ [24s/51s]
Running ‘montecarlo_tests.R’ [45s/89s]
Comparing ‘montecarlo_tests.Rout’ to ‘montecarlo_tests.Rout.save’ ... OK
Running ‘other_tests.R’ [19s/41s]
Comparing ‘other_tests.Rout’ to ‘other_tests.Rout.save’ ... OK
Running ‘pbtk_test.R’ [20s/47s]
Comparing ‘pbtk_test.Rout’ to ‘pbtk_test.Rout.save’ ... OK
Running ‘solve_dermal_test.R’ [13s/23s]
Comparing ‘solve_dermal_test.Rout’ to ‘solve_dermal_test.Rout.save’ ... OK
Running ‘solve_gas_test.R’ [16s/27s]
Comparing ‘solve_gas_test.Rout’ to ‘solve_gas_test.Rout.save’ ... OK
Running ‘testthat.R’ [44s/89s]
Running ‘unit_test.R’ [11s/20s]
Comparing ‘unit_test.Rout’ to ‘unit_test.Rout.save’ ... OK
Running the tests in ‘tests/ivive_test.R’ failed.
Complete output:
> # R CMD BATCH --no-timing --no-restore --no-save ivive_test.R ivive_test.Rout
>
> # Get rid of anything in the workspace:
> rm(list=ls())
>
> library(httk)
>
> # Reduce the number of samples used by Monte Carlo to decrease runtime for
> # CRAN checks (never use predictions with only ten draws):
> NSAMP <- 5
>
> # From Honda et al. (2019) (currently only use mean conc's because steady-state
> # calculation does not give max):
> #
> # Default HTTK function arguments correspond to "Honda3"
> #
> # in vivo Conc. Metabolic Clearance In Vivo Conc. In Vitro Conc.
> #Honda1 Veinous (Plasma) Restrictive Free Free
> #Honda2 Veinous Restrictive Free Nominal
> #Honda3 Veinous Restrictive Total Nominal
> #Honda4 Target Tissue Non-restrictive Total Nominal
> #
> # "Honda1" uses plasma concentration, restrictive clearance, and treats the
> # unbound invivo concentration as bioactive. For IVIVE, any input nominal
> # concentration in vitro should be converted to cfree.invitro using
> # \code{\link{armitage_eval}}, otherwise performance will be the same as
> # "Honda2".
> #
> # Use \code{\link{show_honda.ivive()}} to print summary of Honda et al. (2019)
> # results.
>
> # Default HTTK:
> set.seed(12345)
> Css0 <- calc_mc_css(chem.name="bisphenol a",
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> set.seed(12345)
> # This should be the same as calc_mc_oral_equiv:
> signif(3/Css0,4) ==
+ calc_mc_oral_equiv(3.0,chem.name="bisphenol a",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
uM concentration converted to mgpkgpday dose for 0.95 quantile.
95%
TRUE
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
>
> # Honda1:
> set.seed(12345)
> Css1 <- calc_mc_css(chem.name="bisphenol a",
+ calc.analytic.css.arg.list=list(
+ restrictive.clearance = TRUE,
+ bioactive.free.invivo = TRUE),
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> temp <- armitage_eval(
+ casrn.vector = c("80-05-7"),
+ this.FBSf = 0.1,
+ this.well_number = 384,
+ nomconc = 3)
Error in `[.data.table`(tcdata, IOC_Type_cell == "Base" & is.character(pKa_Accept) & :
attempt access index 92/92 in VECTOR_ELT
Calls: armitage_eval -> %>% -> [ -> [.data.table
Execution halted
Flavor: r-devel-linux-x86_64-fedora-clang
Version: 2.7.4
Check: tests
Result: ERROR
Running ‘3comp_test.R’ [26s/42s]
Comparing ‘3comp_test.Rout’ to ‘3comp_test.Rout.save’ ... OK
Running ‘3compss_test.R’ [22s/36s]
Comparing ‘3compss_test.Rout’ to ‘3compss_test.Rout.save’ ... OK
Running ‘caco2_test.R’ [35s/64s]
Comparing ‘caco2_test.Rout’ to ‘caco2_test.Rout.save’ ... OK
Running ‘cheminfo_test.R’ [14s/27s]
Comparing ‘cheminfo_test.Rout’ to ‘cheminfo_test.Rout.save’ ... OK
Running ‘fetal_pbtk_testing.R’ [17s/32s]
Comparing ‘fetal_pbtk_testing.Rout’ to ‘fetal_pbtk_testing.Rout.save’ ... OK
Running ‘ionization_tests.R’
Comparing ‘ionization_tests.Rout’ to ‘ionization_tests.Rout.save’ ... OK
Running ‘ivive_test.R’ [23s/34s]
Running ‘montecarlo_tests.R’ [44s/60s]
Comparing ‘montecarlo_tests.Rout’ to ‘montecarlo_tests.Rout.save’ ... OK
Running ‘other_tests.R’ [18s/29s]
Comparing ‘other_tests.Rout’ to ‘other_tests.Rout.save’ ... OK
Running ‘pbtk_test.R’ [21s/33s]
Comparing ‘pbtk_test.Rout’ to ‘pbtk_test.Rout.save’ ... OK
Running ‘solve_dermal_test.R’ [13s/35s]
Comparing ‘solve_dermal_test.Rout’ to ‘solve_dermal_test.Rout.save’ ... OK
Running ‘solve_gas_test.R’ [15s/21s]
Comparing ‘solve_gas_test.Rout’ to ‘solve_gas_test.Rout.save’ ... OK
Running ‘testthat.R’ [41s/45s]
Running ‘unit_test.R’ [11s/15s]
Comparing ‘unit_test.Rout’ to ‘unit_test.Rout.save’ ... OK
Running the tests in ‘tests/ivive_test.R’ failed.
Complete output:
> # R CMD BATCH --no-timing --no-restore --no-save ivive_test.R ivive_test.Rout
>
> # Get rid of anything in the workspace:
> rm(list=ls())
>
> library(httk)
>
> # Reduce the number of samples used by Monte Carlo to decrease runtime for
> # CRAN checks (never use predictions with only ten draws):
> NSAMP <- 5
>
> # From Honda et al. (2019) (currently only use mean conc's because steady-state
> # calculation does not give max):
> #
> # Default HTTK function arguments correspond to "Honda3"
> #
> # in vivo Conc. Metabolic Clearance In Vivo Conc. In Vitro Conc.
> #Honda1 Veinous (Plasma) Restrictive Free Free
> #Honda2 Veinous Restrictive Free Nominal
> #Honda3 Veinous Restrictive Total Nominal
> #Honda4 Target Tissue Non-restrictive Total Nominal
> #
> # "Honda1" uses plasma concentration, restrictive clearance, and treats the
> # unbound invivo concentration as bioactive. For IVIVE, any input nominal
> # concentration in vitro should be converted to cfree.invitro using
> # \code{\link{armitage_eval}}, otherwise performance will be the same as
> # "Honda2".
> #
> # Use \code{\link{show_honda.ivive()}} to print summary of Honda et al. (2019)
> # results.
>
> # Default HTTK:
> set.seed(12345)
> Css0 <- calc_mc_css(chem.name="bisphenol a",
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> set.seed(12345)
> # This should be the same as calc_mc_oral_equiv:
> signif(3/Css0,4) ==
+ calc_mc_oral_equiv(3.0,chem.name="bisphenol a",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
uM concentration converted to mgpkgpday dose for 0.95 quantile.
95%
TRUE
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
>
> # Honda1:
> set.seed(12345)
> Css1 <- calc_mc_css(chem.name="bisphenol a",
+ calc.analytic.css.arg.list=list(
+ restrictive.clearance = TRUE,
+ bioactive.free.invivo = TRUE),
+ output.units="uM",
+ samples=NSAMP)
Human plasma concentration returned in uM units for 0.95 quantile.
Warning messages:
1: In get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
2: In get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
3: In get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
4: In (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
calc_analytic_css deprecated argument daily.dose replaced with new argument dose, value given assigned to dose
> temp <- armitage_eval(
+ casrn.vector = c("80-05-7"),
+ this.FBSf = 0.1,
+ this.well_number = 384,
+ nomconc = 3)
Error in `[.data.table`(tcdata, IOC_Type_cell == "Base" & is.character(pKa_Accept) & :
attempt access index 92/92 in VECTOR_ELT
Calls: armitage_eval -> %>% -> [ -> [.data.table
Execution halted
Flavor: r-devel-linux-x86_64-fedora-gcc
Version: 2.7.4
Check: installed package size
Result: NOTE
installed size is 5.1Mb
sub-directories of 1Mb or more:
data 2.1Mb
help 1.5Mb
Flavors: r-oldrel-macos-arm64, r-oldrel-macos-x86_64