PKPDsim: Tools for Performing Pharmacokinetic-Pharmacodynamic Simulations

Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).

Version: 1.4.0
Depends: R (≥ 4.0.0)
Imports: Rcpp (≥ 0.12.9), BH, data.table, stringr, MASS, randtoolbox, jsonlite, stats, parallel, magrittr
LinkingTo: BH, Rcpp (≥ 1.0.13)
Suggests: httr, testthat (≥ 3.0.0), mockery, knitr, rmarkdown
Published: 2024-08-19
DOI: 10.32614/CRAN.package.PKPDsim
Author: Ron Keizer [aut, cre], Jasmine Hughes [aut], Dominic Tong [aut], Kara Woo [aut], Jordan Brooks [aut], InsightRX [cph, fnd]
Maintainer: Ron Keizer <ron at insight-rx.com>
License: MIT + file LICENSE
URL: https://github.com/InsightRX/PKPDsim, https://insightrx.github.io/PKPDsim/
NeedsCompilation: yes
Materials: README NEWS
In views: MixedModels, Pharmacokinetics
CRAN checks: PKPDsim results

Documentation:

Reference manual: PKPDsim.pdf
Vignettes: Covariates (source, R code)
Absorption models (source, R code)
Export model (source, R code)
Model (source, R code)
Output (source, R code)
Parameters (source, R code)
Regimen (source, R code)
Simulation (source, R code)
Speed (source)

Downloads:

Package source: PKPDsim_1.4.0.tar.gz
Windows binaries: r-devel: PKPDsim_1.4.0.zip, r-release: PKPDsim_1.4.0.zip, r-oldrel: PKPDsim_1.4.0.zip
macOS binaries: r-release (arm64): PKPDsim_1.4.0.tgz, r-oldrel (arm64): PKPDsim_1.4.0.tgz, r-release (x86_64): PKPDsim_1.4.0.tgz, r-oldrel (x86_64): PKPDsim_1.4.0.tgz
Old sources: PKPDsim archive

Linking:

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