POSTm: Phylogeny-Guided OTU-Specific Association Test for Microbiome
Data
Implements the Phylogeny-Guided Microbiome OTU-Specific Association
Test method, which boosts the testing power by adaptively borrowing
information from phylogenetically close OTUs (operational taxonomic units)
of the target OTU. This method
is built on a kernel machine regression framework and allows for flexible
modeling of complex microbiome effects, adjustments for covariates, and
can accommodate both continuous and binary outcomes.
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