Overview

SIGN fasciliotates classification and clustering of biological samples relyign on expression pattersn of biological pathways. A new measure of pathway expression pattern similarity (TSC) was introduced in the package. The package has been developed and tested for RNA-seq profiles of the cells. However, it can be used for other sequencig profiles with continuous values for each feature (gene, protein, cis-regulatory elements, etc.)

Installation

``` r # Install from CRAN install.packages(‘SIGN’)

Installing the development version from GitHub:

install.packages(“devtools”)

devtools::install_github(“bhklab/SIGN”)