mcradds
The mcradds
R package is a complement to
mcr
package, contains common and solid functions for
designing, analyzing and visualization in In Vitro Diagnostic trials.
Most of the methods and algorithms refer to CLSI recommendations and
NMPA guidelines.
The package provides a series of typical functionality, as shown
below:
- Estimation of sample size for trials, NMPA guideline.
- Diagnostic accuracy with/without standard/golden reference, CLSI
EP12-A2.
- Regression analysis and plot in method comparison, CLSI
EP09-A3.
- Bland-Altman analysis and plot in method comparison, CLSI
EP09-A3.
- Outlier detection with 4E method from CLSI EP09-A2 and ESD from CLSI
EP09-A3.
- Evaluation of bias in medical decision level, CLSI EP09-A3.
- Pearson and Spearman correlation adding hypothesis test and
confidence interval.
- Establishing of Reference Range/Interval, CLSI EP28-A3 and NMPA
guideline.
- Paired ROC/AUC test for superiority and non-inferiority trials, CLSI
EP05-A3/EP15-A3.
- Reproducibility analysis (reader precision) for immunohistochemical
assays, CLSI I/LA28-A2 and NMPA guideline.
- Evaluation of precision of quantitative measurements, CLSI
EP05-A3.
- Descriptive statistics summary.
Installation
mcradds
is available on CRAN and you can install the
latest released version with:
install.packages("mcradds")
or you can install the development version directly from GitHub
with:
if (!require("devtools")) {
install.packages("devtools")
}
devtools::install_github("kaigu1990/mcradds")
See package vignettes
browseVignettes(package = "mcradds")
for usage of this
package.